Are the substances critical to your business going to be registered? ECHA maintains a <link https: www.echa.europa.eu view-article journal_content title list-of-substances-with-lead-registrants-available _blank>list of substances for which there is visible progress - the substance is already registered or, as a minimum, the lead registrant has started the work towards joint registration in REACH-IT. If you don't know whether your critical substances are registered (no registration number in the safety data sheet) or not, and can't find them on the list, contact your suppliers and ask about their registration intentions. The list is updated on a monthly basis.